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You will find our biotecnology projects in the following categories
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Diagnostic
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Novel miRNA biomarker and treatment of memory impairment
Age associated dementia consist a serious health and social problem for our society, with their prevalence increasing as lifespan expands. Efficient therapeutic strategies to treat memory decline are still missing. Scientists of the University of Göttingen have now developed a new biomarker and medical approach for treatment of dementia and of other memory impairment conditions. This includes discovery of a new microRNA (miRNA) biomarker associated with learning and memory and its therapeutic manipulation, in particular to rescue learning impairment in dementia.
Projekt Summary (PDF)
[more...]
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Monoclonal Antibodies against several Pox Viruses
Scientists at the Georg-August-University generated monoclonal antibodies against several pox viruses as against bird pox (Canarypoxvirus, Fowlpoxvirus), against bovine Coronavirus and against orthopoxvirus and parapoxvirus. Bovine coronavirus may cause acute diarrhea in newborn calves, even increasing the morbidity rate, and can lead to significant economic losses. Definitive diagnosis of an enteric coronavirus infection is achieved by performing electron microscopy or an ELISA on a faecal or tissue sample.
Projekt Summary (PDF)
[more...]
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New genetic markers for transplant rejection
In cardiovascular, respiratory, kidney and haematological diseases transplantation remains the most effective long term therapy for patients with advanced organ failure. In addition, hematopoietic stem cell transplantation (HSCT) for the treatment of lymphoproliferative disorders and leukemias has recently become an important mainstay in oncology. There is an urgent need for non-invasive, predictive and diagnostic monitoring to improve outcomes. The global market for transplant diagnostics is projected to grow at 12% CAGR to reach $553 million in 2015. This market is part of of the growing transplantation market with an $80 billion market value expected in 2015.
Projekt Summary (PDF)
[more...]
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Antibody Therapy and Diagnosis of Alzheimer's Disease (AD)
Alzheimer's Disease Therapy based on Göttinger proprietary Antibody, incl. companion diagnostic methodology.
Projekt Summary (PDF)
[more...]
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New biomarkers for the Diabetic Nephropathy Diagnosis
Diabetes is, after arterial hypertension, the 2nd most common disease in industrialized countries. Identification of markers for the prediction of the clinical course of diabetic nephropathy is a major challenge in disease management. Scientists at the University of Göttingen identified several novel biomarkers in urine for the diagnosis of diabetic nephropathy.
Projekt Summary (PDF)
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Enzymes
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New enzyme for the conversion and binding of the greenhouse gas carbon dioxide (CO2)
Scientists from the University of Göttingen found new members of carbonic anhydrase from a living fossil, a coralline sponge, major contributors to reef building processes. Carbonic Anhydrase is a family of metalloenzymes that catalyse the conversion of carbon dioxide, the most abundant greenhouse gas whose elimination seems to be crucial to slow down global warming.
Projekt Summary (PDF)
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New enzyme for the conversion and binding of the greenhouse gas carbon dioxide (CO2)
Scientists from the University of Göttingen found new members of carbonic anhydrase from a living fossil, a coralline sponge, major contributors to reef building processes. Carbonic Anhydrase is a family of metalloenzymes that catalyse the conversion of carbon dioxide, the most abundant greenhouse gas whose elimination seems to be crucial to slow down global warming.
Projekt Summary (PDF)
[more...]
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9/13 Divinylethersynthase
Novel 9/13 Divinylethersynthase for the enzymatic production of aldehydes, alcohols and esters from fatty acids.
Projekt Summary (PDF)
[more...]
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Oncology
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Novel combi treatment to boost efficacy of antibody therapies
Antibody-mediated therapies have evolved as a mainstay of targeted anti-cancer therapy but also of auto-immune and other diseases. However, antibody drug resistance during treatment and thus poor performance are one of the major obstacles for efficient therapy. Scientists of the University of Göttingen have now developed a new treatment regime of a combined drug administration, improving the efficacy of the antibody response.
Projekt Summary (PDF)
[more...]
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New genetic markers for transplant rejection
In cardiovascular, respiratory, kidney and haematological diseases transplantation remains the most effective long term therapy for patients with advanced organ failure. In addition, hematopoietic stem cell transplantation (HSCT) for the treatment of lymphoproliferative disorders and leukemias has recently become an important mainstay in oncology. There is an urgent need for non-invasive, predictive and diagnostic monitoring to improve outcomes. The global market for transplant diagnostics is projected to grow at 12% CAGR to reach $553 million in 2015. This market is part of of the growing transplantation market with an $80 billion market value expected in 2015.
Projekt Summary (PDF)
[more...]
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Decapeptide Combi-Therapy of (resistant) steroidal cancers
Innovative Decapeptides for the therapy of (resistent) steroidal cancer, like e.g. breast-, ovarial-, endometrium- or prostate carcinoma, in combination with Tamoxifen, Fulvestrant,etc...
Projekt Summary (PDF)
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Prodrug for tumor therapy
Scientists of the University of Göttingen developed new highly potent drugs (with an IC50 in the pico-Molar range) as well as a selective tumor therapy through their prodrugs based on the Antibody Directed Enzyme Prodrug Therapy (ADEPT). Selective is achieved by the specific tumor targeting through the antibody. The highly soluble prodrugs are activated into the cytotoxic drugs only at tumor site through the enzyme, which is coupled to the antibody. While prodrugs have a low cytotoxicity, active drugs show an unbelievable cytotoxicity in the pico-molar range, much higher than actually used Doxorubicin. The drugs could be used equivalent to current chemotherapeutic agents or combined with e.g. a targeting-antibody.
Projekt Summary (PDF)
[more...]
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Therapy of Steroid Related Cancers
Steroid-related cancer types have the highest incidence among tumors. Scientists at the University of Göttingen developed new antagonists to a selected target receptor for the therapy of steroidal cancers, which potentially could also be used to treat malignant melanoma. In vivo proof of concept has been achieved.
Projekt Summary (PDF)
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Vaccination against Malignant Melanoma and other Carcinomas
Inventors from the Georg-August-University Göttingen identified an antigen, which promises to be the basis for an efficient prophylactic vaccine against malignant melanoma and other carcinomas.
Projekt Summary (PDF)
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Stem Cells
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Universal Regeneration System based on somatic Stem Cells for Therapy and Tissue Repair
Stem cells promise to be the key for a multitude of therapeutic approaches. Scientists at the University of Goettingen identified a new biological Universal Regeneration System (URS) for therapy and tissue repair, which is based on somatic stem cells. These unique stem cells are easily accessible and cultured, they show a spontaneously high pluripotency, and they have been proved in vivo.
Projekt Summary (PDF)
[more...]
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Central Nervous System
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Novel miRNA biomarker and treatment of memory impairment
Age associated dementia consist a serious health and social problem for our society, with their prevalence increasing as lifespan expands. Efficient therapeutic strategies to treat memory decline are still missing. Scientists of the University of Göttingen have now developed a new biomarker and medical approach for treatment of dementia and of other memory impairment conditions. This includes discovery of a new microRNA (miRNA) biomarker associated with learning and memory and its therapeutic manipulation, in particular to rescue learning impairment in dementia.
Projekt Summary (PDF)
[more...]
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Antibody Therapy and Diagnosis of Alzheimer's Disease (AD)
Alzheimer's Disease Therapy based on Göttinger proprietary Antibody, incl. companion diagnostic methodology.
Projekt Summary (PDF)
[more...]
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New animal model for sporadic Alzheimer's Disease (AD)
New developed transgene Animal Model for the sporadic Alzheimer's Disease (AD) to be used in the AD research and for the development of AD drugs....
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Antibodies
Scientists at the Georg-August-University Göttingen generated many different monclonal antibodies. We are looking for companies, who are interested in licensing these antibodies for selling them to industrial and scientific institutions or for developing advanced diagnostic tests and therapeutic solutions.
This unique collection comprises the listed clones:
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Monoclonal Antibodies against several Pox Viruses
Scientists at the Georg-August-University generated monoclonal antibodies against several pox viruses as against bird pox (Canarypoxvirus, Fowlpoxvirus), against bovine Coronavirus and against orthopoxvirus and parapoxvirus. Bovine coronavirus may cause acute diarrhea in newborn calves, even increasing the morbidity rate, and can lead to significant economic losses. Definitive diagnosis of an enteric coronavirus infection is achieved by performing electron microscopy or an ELISA on a faecal or tissue sample.
Projekt Summary (PDF)
[more...]
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Antibody Therapy and Diagnosis of Alzheimer's Disease (AD)
Alzheimer's Disease Therapy based on Göttinger proprietary Antibody, incl. companion diagnostic methodology.
Projekt Summary (PDF)
[more...]
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Prodrug for tumor therapy
Scientists of the University of Göttingen developed new highly potent drugs (with an IC50 in the pico-Molar range) as well as a selective tumor therapy through their prodrugs based on the Antibody Directed Enzyme Prodrug Therapy (ADEPT). Selective is achieved by the specific tumor targeting through the antibody. The highly soluble prodrugs are activated into the cytotoxic drugs only at tumor site through the enzyme, which is coupled to the antibody. While prodrugs have a low cytotoxicity, active drugs show an unbelievable cytotoxicity in the pico-molar range, much higher than actually used Doxorubicin. The drugs could be used equivalent to current chemotherapeutic agents or combined with e.g. a targeting-antibody.
Projekt Summary (PDF)
[more...]
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Anti-rat C5a Receptor
Licensee sought!
Projekt Summary (PDF)
[more...]
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Mouse anti-human PIWIL2 mAb
Licensee sought!
Projekt Summary (PDF)
[more...]
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Mouse anti-human beta2-adrenergic receptor mAb
Licensee sought!
Projekt Summary (PDF)
[more...]
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Mouse anti-human Il-8 Receptor mAb
Licensee sought!
Projekt Summary (PDF)
[more...]
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Mouse anti-human complement Factor H mAb
Licensee sought!
Projekt Summary (PDF)
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Rat anti-murine Chemokine Receptor 9 (Cdw199) mAb
Licensee sought!
Projekt Summary (PDF)
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Mouse anti-human / anti-rat beta-arrestin 1,2
Licensee sought!
Projekt Summary (PDF)
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Anti-human C5a Receptor (C5aR / CD88); anti-C5aR-pSer334 (PKC site)
Licensee sought.
Projekt Summary (PDF)
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Monoclonale Antibodies: Anti-human/anti-rat/anti-mouse C3a-Rezeptor
Licencee sought!
Projekt Summary (PDF)
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Anti-human Chemokine Receptor 5 (CCR5 / CD195); anti-CCR5-pSer 337 (PKC-site); anti-CCR5-pSer349 (GRK site)
Licensee sought!
Projekt Summary (PDF)
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Anti-human / anti-porcine Complement protein
Licensee sought
Projekt Summary (PDF)
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Anti-mouse Chemokine Receptor 7 (CCR7)
Licensee sought!
Projekt Summary (PDF)
[more...]
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Research Tools
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Monoclonal Antibodies against several Pox Viruses
Scientists at the Georg-August-University generated monoclonal antibodies against several pox viruses as against bird pox (Canarypoxvirus, Fowlpoxvirus), against bovine Coronavirus and against orthopoxvirus and parapoxvirus. Bovine coronavirus may cause acute diarrhea in newborn calves, even increasing the morbidity rate, and can lead to significant economic losses. Definitive diagnosis of an enteric coronavirus infection is achieved by performing electron microscopy or an ELISA on a faecal or tissue sample.
Projekt Summary (PDF)
[more...]
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New animal model for arthritic diseases
Arthritic diseases are conditions involving damages to the joints and/or cartilage. Osteoarthritis is the most common form of arthritis, which affects over 200 million people worldwide. The pharmaceutical market for arthritis generated $15.9 billion in revenues in 2008. Scientists of the University of Göttingen have now developed a new animal drug screening model for arthritic diseases, which is caused by dysfunction of the Hedgehog pathway specifically in chondrocytes.
Projekt Summary (PDF)
[more...]
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New animal knock-out system to study dysfunction of chondrocytes
Arthritic diseases are conditions involving damages to the joints and/or cartilage, mostly due to dysfunction of chondrocytes. Osteoarthritis is the most common form of arthritis, which affects over 200 million people worldwide. The pharmaceutical market for arthritis generated $15.9 billion in revenues in 2008. Scientists of the University of Göttingen have now developed a new animal drug screening model for arthritic diseases, which is caused by dysfunction of the Hedgehog pathway specifically in chondrocytes.
Projekt Summary (PDF)
[more...]
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Antibody Therapy and Diagnosis of Alzheimer's Disease (AD)
Alzheimer's Disease Therapy based on Göttinger proprietary Antibody, incl. companion diagnostic methodology.
Projekt Summary (PDF)
[more...]
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New animal model for sporadic Alzheimer's Disease (AD)
New developed transgene Animal Model for the sporadic Alzheimer's Disease (AD) to be used in the AD research and for the development of AD drugs....
[more...]
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Culture Collection of Algae (SAG)
The Culture Collection of Algae at the Georg August University Göttingen (SAG) is one of the three largest collections of living microscopic algae.
Projekt Summary (PDF)
[more...]
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RBL-Cell-Lines
RBL-cell lines overexpressing several receptors offered by the University of Göttingen
Projekt Summary (PDF)
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RBL-C5aR cell line
Scientists at the University of Göttingen developed a transfectant RBL-C5aR cell line which is able to express more than 1 million C5a receptors on its cell surface, showing a specific high Ca2+ signal. The generated RBL-cells express C5aR in a number of „flavours“ (FLAG-tagged, N-glycosilation deficient, phosphorylation-deficient, co-transfected with other GPCR). C5aR(CD88) binds to C5a, an important chemotactic protein, element of the biochemical cascade of the complement system. This cell line would make the development of a standardized assay easy, fast, reproducible and sensitive.
Projekt Summary (PDF)
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